So, incorrectly labeled non-annotated genes = 100% of errors assigned to non-annotated group if symmetric → <<200=200>>200.

Thu, 16 Apr 2026 14:25:39 +0000

Title: The Critical Impact of Correctly Labeling Non-Annotated Genes: Why 100% of Errors Assigned to Non-Annotated Groups Isn’t Just a Statistic — It’s a 200-Fold Breakdown of Diagnostic and Biological Consequences --- Introduction In genomics, accurate gene annotation is foundational for meaningful research, clinical diagnostics, and therapeutic development. Yet, a persistent challenge undermines reliability: genes that remain incorrectly labeled or unannotated, especially when symmetric misclassification leads to cascading errors. Recent analysis reveals a stark truth—if errors are symmetrically distributed among non-annotated genes, approximately 100% of misannotations are assigned to this group—a result quantified at 200 errors per dataset, emphasizing systemic labeling flaws.